Since Biolux was founded in 2007, research and collaboration with experienced researchers has been embedded in our DNA.

Ten-Year Partnership with INSERM and INM

An exclusive collaboration signed with an INSERM team based at the Institute for Neurosciences of Montpellier (INM) allowed Biolux to understand photomodulation’s action mechanism.

Biolux’s Expertise

Our R&D team’s multidisciplinary expertise has enabled us to validate our treatments’ effectiveness on various levels.

From Research to Real-Life Application

Biolux’s medical progress started with foundational research followed by translational and clinical research to make this technology available for humans.

Four Foundational Focuses

Research and development on photomodulation research programmes were based on four focus areas, around which all protocols were developed:
Healing – Inflammation – Regeneration – Pain

In Vitro Level
Various tests highlighted the role photomodulation played in cell migration, proliferation and differentiation, as well as in regulating inflammation.

Published Article
Validation de l’action des LEDs sur la vitesse de pousse neuritique des neurones sensoriels (Validating LED Action on Speed of Neurite Growth in Sensory Neurons): in axotomic conditions, the rate of neuritic growth obtained after an LED stimulation reached a threshold never equalled in the articles available in the literature.

In Vivo Level
The transition before applying clinical stimulation protocols. The tests carried out on more integrated models validated the various results obtained on the cellular level.

Translational Level
Knowledge and technology transferred to therapeutic application. Professional devices and home care models were created for clinical use.

Clinical Level
An international clinical study was conducted in partnership with a Brazilian team to evaluate the effect photomodulation has on scars from abdominal plastic surgery. This study definitively validated Biolux technology’s effect on the four research focus areas, all involved in the post-surgical healing process.

Constant Investment

Biolux continues to invest in R&D because we are committed to continuous improvement and exploring innovative therapeutic possibilities. We do this by:

  • developing new academic and industry partnerships (collaborations with well-known physicians and clinics)
  • relying on our multidisciplinary R&D team
  • offering new functionalities for evolving and increasingly-innovative devices

Photomodulation Bibliography

Photomodulation’s strong therapeutic potential has led to numerous publications covering a wide range of applications.

Foundamental Research (Partial List)

Burland, M, Paris L. et al. (2014), Neurite growth acceleration of adult Dorsal Root Ganglion neurons illuminated by low-level Light Emitting Diode light at 645 nm ; J. Biophotonics 1-9 (2014)/DOI 10.1002/jbio.201400052
Basha A. A et al (2016) Effect of LED photobiomodulation on fluorescent light induced changes in cellular ATPases and Cytochrome c oxidase activity in Wistar rat ; J Drugs Dermatol. 2016 Jul 1;15(7):843-8.
Silveira PC et al. (2016) Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on Inflammatory Response in Burn Wound Healing ; Inflammation. 2016 Aug;39(4):1395-404. doi: 10.1007/s10753-016-0371-x.
Lee WJ et al. (2016) Efficacy of Red or Infrared Light-Emitting Diodes in a Mouse Model of Propionibacterium acnes-Induced Inflammation ; Ann Dermatol. 2016 Apr;28(2):186-91. doi: 10.5021/ad.2016.28.2.186. Epub 2016 Mar 31.
Leite SN et al. (2014) Phototherapy promotes healing of cutaneous wounds in undernourished rats ; An Bras Dermatol. 2014 Nov-Dec;89(6):899-904.
Spitler Ret al. (2014) Comparison of laser and diode sources for acceleration of in vitro wound healing by low-level light therapy ; J Biomed Opt. 2014 Mar;19(3):38001. doi: 10.1117/1.JBO.19.3.038001.
Piva, J. A. d. A. C. (2011) Effect of low-level laser therapy on the initial stages of tissue repair: basic principles ; Anais Brasileiros de Dermatologia.
Huang, Y. Y., A. C. Chen, et al. (2011). Biphasic dose response in low level light therapy – an update ; Dose Response. 2011;9(4):602-18. doi: 10.2203/dose-response.11-009.Hamblin. Epub 2011 Sep 2.
Huang, Y. Y., A. C. Chen, et al. (2009). Biphasic dose response in low level light therapy ; Dose Response 2009 Sep 1;7(4):358-83. doi: 10.2203/dose-response.09-027.Hamblin.
Albertini, R., A. B. Villaverde, et al. (2007). « Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660 nm and 684 nm) in carrageenan-induced rat paw edema. » J Photochem Photobiol B 89(1): 50-55.

Clinicals investigations (partial list)

LEDs & Soft Peels _ Evaluation de la complémentarité de deux technologies pour lutter contre le vieillissement cutané, Dr. Jean-Luc Vigneron. Résultats présentés à SECLARM, Genève, en 2014

Yoo KH et al. (2015) Efficacy of combination light-emitting diode (635 and 830 nm) therapy in treating local injection-site reactions after filler ; Clin Exp Dermatol. 2015 Apr;40(3):333-5. doi: 10.1111/ced.12480. Epub 2014 Sep 30.

Calderhead RG et al. (2015) Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures ; Laser Ther. 2015 Dec 30;24(4):277-89. doi: 10.5978/islsm.15-OR-17.
Oh IY (2013) Efficacy of light-emitting diode photomodulation in reducing erythema after fractional carbon dioxide laser resurfacing: a pilot study ; Dermatol Surg. 2013 Aug;39(8):1171-6. doi: 10.1111/dsu.12213. Epub 2013 Apr 3.
Lee, S. Y., K. H. Park, et al. (2007). A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings ; J Photochem Photobiol B 88(1): 51-67.